منابع مشابه
Synthesis of Some New Pyridazine Derivatives for Anti-HAV Evaluation.
4-(2-(4-Halophenyl)hydrazinyl)-6-phenylpyridazin-3(2H)-ones 1a,b were prepared and treated with phosphorus oxychloride, phosphorus pentasulphide and ethyl chloroformate to give the corresponding chloropyridazine, pyridazinethione, oxazolopyridazine derivatives 2-4, respectively. Compound 2 reacted with hydrazine hydrate to afford hydrazinylpyridazine 7. The reaction of 4-(2-(4-chlorophenyl)hydr...
متن کاملSynthesis and Anti Cancer Activity of Pyrido[2,3-c]Pyridazine Derivatives
Cancer is not just one disease, but a large group of almost one hundred diseases. Its two main characteristics are uncontrolled growth of the cells in the human body and the ability of these cells to migrate from the original site and spread to distant sites. If the spread is not controlled, cancer can result in death. There has been continuous progress in the development of therapy for cancer....
متن کاملSynthesis of Some Novel Pyridazine, Thienopyridazine, Pyrazolopyridine, Pyridopyrazolopyrimidine and Pyridopyrazolotriazine Derivatives with Their Antimicrobial Activity
Coupling of compound 1 with diazotized aromatic amines in ethanol afforded the arylhydrazones 3a,b. Fusion of 3a,b with active methylene derivatives 4a,b afforded the pyridazine derivatives 6a–d. Also, when compounds 6b,c were reacted with elemental sulphur afforded the thienopyridazine derivatives 7a,b. Treatment of compound 8 with hydrazine hydrate produced pyrazolopyridine derivative 9. Pyri...
متن کاملSynthesis and antiviral activities of 3-aralkylthiomethylimidazo[1,2-b]pyridazine derivatives.
The synthesis of novel substituted 3-aralkylthiomethylimidazo[1,2-b]pyridazines is reported. All of the synthesized compounds are devoid of antiviral activity against the replication of human immunodeficiency virus. However, compounds 6-chloro-8-methyl-3-phenethylthioimidazo[1,2-b]pyridazine and 6-chloro-2-methyl-3-phenethylthioimidazo[1,2-b]pyridazine are potent inhibitors of the replication o...
متن کاملSynthesis of Some Bioactive Sulfonamide and Amide Derivatives of Piperazine Incorporating Imidazo[1,2-B]Pyridazine Moiety
Sulfonamide and amide derivatives comprise an important class of drugs with diverse biological applications. Sulfonamides are widely used as antimicrobial [1,2], anticancer [3,4], anti-inflammatory [5] and antiviral agents as well as HIV protease inhibitors [6]. Sulfonamides were the first effective chemotherapeutic agents to be utilized efficiently to prevent and cure the bacterial infection i...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1962
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.82.2_253